DSLR Shots and Discussions

Tigger

Need some opinions. I'm starting up a professional photography business and I plan on doing about half of my work with models/portraiture and weddings. The other half split between landscape, astro-photography and street.

I put some contenders up for consideration. Initial budget is $40k. I'm only looking for two cameras. One super portable for street and the other for the no-joke, all-out quality camera.

For indoor portrait work/weddings and also landscape/astrophotography:

Leica S (type 007) with Summicron 100mm f/2 ASPH and various fast lenses of various lengths
-OR-
Canon 5D Mark IV with Zeiss 55mm 1.4 distagon and other fast lenses as applicable

For street...
Leica Q (type 116) with fixed 28mm lens
Any other suggestions? Looking for something small and easy to carry, handle, and manipulate settings on the fly without having to dig through menus (like the Sony A7r ii for example)
Nikon D750 (or the new equivalent, if there ever is one, as long as proportions don't expand) would be a contender here.

What I've listed is highly limited and I am open to suggestions as long as everything stays in the full-frame to medium format realm. DOF will be an enormous factor as I am approaching photography from an artistic standpoint in all facets including weddings.

Thanks in advance for your thoughts!

Edit: Added Fujifilm GFX 50S medium format camera to the mix (not yet released).