Sure it can man, you need to know what you are doing, any variable with in your ECU can seriously F you up.
A decent tuner will be able to get teh best from your set up, variable Cam timing is nothing new, but it is un known presently how the VQ platform will react short term or long term, guess we will find out.
In short though too much advance will bog you down, mess your fueling and your timing, screw with your EGT's etc etc, too much retard will not allow enough air flow and can cause a slow revving sluggish top end, you get the picture? as with evrything, all about balance.
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Boosted V8 hunter
2850 lbs and 375WHP
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