Most injectors run a 12V source hot (key on) all the time. The ECU grounds the other pin to fire the injector. It sounds like you have a hard short to ground in the harness or an injector. Start by disconnecting the injector harness and see if it still blows the fuse. Divide and conquer.
(Typical injector impedance is 10-12 Ohms, so they should pull about 1 Amp if they are working properly.)
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