Originally Posted by Spstone

Honestly with all the advancements in ammunition it comes down to what you are comfortable with shooting and find a frame that fits your hands, and body if carrying. If you look at the gels of rounds from .380 to .45 that are designed for extreme trauma they all have the power to stop the bad guy. But if you choose to run around with a .45 because some one told you it's the best, but only have the strength to shoot a .380 you aren't going to hit the bad guy and that big round is useless. Just my 2 pennies.