Yeah the rim is a tad wide but it will still work given the relatively tall sidewall.
You could also run 245/45 R18 on all 4 but as Schrute already mentioned the 225/50 will do slightly better in the snow and ice due to having a smaller contact patch and narrower tread.
The staggered setup will work as well but the rear end will be a little more loose in the worst conditions. Overall the difference is less than 10% so not a huge deal.
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