i have cleaned my throttle body on my G35 and my 370z and i removed them each time to get the inside clean i think as long as you dont push on the throttle plate and move it when its off you shouldnt have to do any reset . ive never had to . i think i unhooked the negative before i did it but not sure if even that is necessary if the car is off and i have re routed the coolant lines that were attached to them . the coolant still flows but no longer heats the throttle body.