You want to have
one in your home for protection? Hmm....I have a loaded gun in every room in my house. Guess that's a bit of overkill, huh?
In all seriousness though, you might also want to take a look at the Sig P226. It's a 9mm, shoots very smoothly recoil-wise (which is important for a beginner), and it's good quality. Glocks are good too as far as economical and reliable guns go, but the lack of a manual safety or heavy DA trigger on Glocks makes me a little nervous when it comes to novice gun owners. Another nice thing about Sigs is that they usually ship with night sights standard. You can get Glocks with night sights, but they usually ship without them. I wouldn't bother with a .22 for defense.
Here's a link for the Sig 226:
http://www.sigsauer.com/Products/Sho...7&productid=90