I look at it this way... I work in a research lab and went to Hopkins to study molecular microbiology and immunology. I'm not cool. I've never been cool, and I'm not going to be cool in the future, even if I buy a Veyron. So screw it.
I wave to people who wave to me, but I've always thought it was more of a motorcycle thing than a car thing. And speaking of which, it was funny how back when I had a Harley the HD guys would wave and sport bike guys wouldn't, but now that I own a Ducati it's the HD guys that turn their noses up while the sport bike guys (well, most of them) return my wave.
I'm done with the "wave." I'll ride/drive what I like and DGAF what everyone else thinks.