In 1990 I took a perfectly good 73 240Z, ripped out the perfectly good stock straight six and manual tranny, and replaced it with a mildly worked over Chevy 350 backed by a M21 Rockcrusher. Even ran the stock rear end for about a year. The fabrication costs alone made the project a $$$ loser from day one, but, what can I say. Had to do it over again, I would have put my $$ elsewhere.
Point is, if you have $$ to throw away, and realize the car won't be worth a fraction of what you put into it, are ready for the headaches of trying to fit a square peg in a round hole, and will most likely be tired of it three months after you finish it (if you do...), then freaking go for it!
P.S. I realize I haven't told you anything you didn't already know.
Best of luck with that.....