Yes and no. If you want to do a coaxial speaker you would be able to use an adapter and just install it in the door. however you would have to unplug your tweeter in the dash otherwise it would sound pretty bad. So yes but you would lose quality and imaging.
If you installed a component set installing the woofer in the door and installing the tweeter in the factory location. The set would include a crossover you would use as we. That would be the best way to go but you would have to run new speaker wire, which really is not that hard.
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