To throw my two cents in, it's a little long but read. Shoes will make the difference as it was stated before. Strtengthening your legs will help tremendously to endure the weight being moved. A couple of things I didn't see covered:
You should also know HOW to run. A lot of individuals do the mistake of heel striking as they run, which in the long run (no pun intended), can give you shin splints. Typically, you want to run on the ball of your foot.
JohnSZ, covered all the things in a general sensus, but keeping a good diet will help out a lot more and you will see results a lot faster. If you stick to the outside edges of a grocery store, the healthier the food.
Hydration is key, a powerade will give you a tiny boost but it cannot hydrate you as you run. You should be hydrated a day prior and of the run days...actually any day in general. This is why you are cramping up. I drink about 1-2 liters of water a day and about 3 on a workout day.
Last thing, I have for you is to set your own goal. Don't try to do someone else's. This is how one could lose interest and quit. Have fun on your runs and remember to warm up your body before the run and strecth each muscle 30 secs or more to actually have effect.
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Stillen Intake, ARK Exhaust. Hopefully in the near future  : Tanabe GF210 Lowering Springs, Hotchkis Sway Bars, Motordyne M370 Intake Manifold.
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