Honestly the Holland is the better choice; however 6th Ave is a pain in the ***, and the drive all the way up to 44th St may become the longest and quite possibly the scariest drive of your life (Taxi's, pot holes, and various other a-holes).
Although I'd take the Z into the city (I drove into the meatpacking dist. last night @ around 7pm, and I'll be going out into the city again tomorrow night for restaurant week.), it's definitely a tiring affair for stick drivers, and if you're not really familiar with the city's streets and traffic, then it's almost a nightmare. That being said, I still voted for take the Z, haha, and best of luck to you tomorrow. Hope you enjoy your stay in the city.
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